| 발행년도/권호 |
2012 년 / 권호: V.24,no.3,Sept |
| 논문제목1(원어) |
아토피성 피부염병변에 치료효과가 있는 천연염료 연구(2 )-솔잎 추출물- |
| 논문제목2(타언어) |
A Study on Natural Dye Having the Effects on the Atopic Dermatitis (Part2 )- Pine Needles Extract - |
| 저자(원어) |
이정순 · 우효정 |
| 저자(타언어) |
충남대학교 의류학과 |
| 소속(원어) |
Jung Soon Lee and Hyo Jung Woo |
| 소속(타언어) |
Chungnam National University |
| 시작/끝
페이지 |
196 ~ 203 총페이지 : 8 |
| 언어(원어) |
Korean |
| 초록 |
Abstract: The purpose of this study was to investigate usefulness of the pine needles extract on Atopic Dermatitis(AD)-like
skin lesions. To investigate the effect of pine needles extract in vivo, atopic dermatitis (NC/Nga) mice using DNCB
(2.4-Dinitrochlorbenzene) was used. NC/Nga mice were challenged with DNCB during 2 weeks to develope AD-like skin lesion.
After that, pine needles extract was applied to AD-like skin lesion on the backs of the NC/Nga mice during 3 weeks. The
efficacy of pine needles extract in the NC/Nga mice was evaluated by measurement of the skin lesion severity(NC mouse
score), the serum IgE level, epidermal thickness changes, and mast cell number. Blood was collected from the retro-orbital area
and the level of IgE in the blood was measured. The epidermal thickness and mast cell number were observed by microscopic
method after H&E stain. The serum IgE levels were decreased after treatment with pine needles extract. The epidermal thickness
and mast cell number were decreased after treatment with pine needles extract. To conclude, the topical application of pine
needles extract suppressed the progression of AD-like skin lesion. |
| 키워드 |
Keywords: pine needles extract, natural dye, atopic dermatitis, NC/Nga mice, DNCB |
| 학회지 |
|
| Reference |
http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=OSGGBT_2012_v24n3_196 |
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